Endocrine Abstracts

Irisin is a myokine involved in the browning of white adipose tissue and in the regulation of energy expenditure, glucose tolerance and insulin sensitivity. It was previously demonstrated that obese adults with Prader-Willi syndrome (PWS) harbor lower irisin levels than individuals with common obesity. Significant associations seem to relate irisin to muscle mass, REE, insulin resistance and triglycerides and also the strongest independent predictors of irisin levels were PWS ...

Introduction: Hypothalamic–pituitary anomalies are well proven in Prader–Willi syndrome (PWS). In this context, it has been previously reported that central adrenal insufficiency (CAI) may be part of the PWS phenotype. However, the diagnostics of CAI is critical and debated, due to the lack of fully reliable tests. Several studies have looked at the clinical usefulness of the low dose (1 μg) short Synacthen test (LDSST) compared to the conventional dose (250 &#9...